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Take action levonorgestrel 1.5 mg i.v. with d,l-norgestimate 20 mcg/12 h, levonorgestrel 30 mcg im. In three pregnancies, d,l-norgestimate resulted an increased rate of pregnancy loss; we did not observe it in any pregnancies of women not using any these drugs. However, no women with d,l-norgestimate or levonorgestrel use had unintended pregnancies, suggesting that contraceptive effectiveness could be maintained with no or slight increases in hormone doses when these drugs are withdrawn for at least 12 weeks after unprotected sex. Data on postpartum use of these drugs are inconclusive. Molecular mimicry in estrogen-like ligands Some compounds, including dl-dextropropoxyphene (DPHP) and norethindrone acetate (NPA), that have been thought to mimic estrogen, may also be estrogen-like. Some drugs mimic all forms of estrogen or some combinations thereof. NSP, for example, mimics estrogen in three ways, both vitro and in vivo. NSP inhibits progesterone biosynthesis in a fashion similar to that of estradiol. NSP also inhibits the expression of estrogen receptors, a process also associated with estrogen synthesis. The potency of norethindrone acetate and DPG (10, 20, 30 mcg) was similar, approximately 100 times lower than the average estradiol concentration in normal human milk. NSP is a strong and persistent inhibi