Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus in the body. It will not cure herpes, but it can lessen the symptoms of the infection. Acyclovir is used to treat infections caused by herpes viruses, such as genital herpes, cold sores, shingles, and chicken pox.
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Acyclovir 800 mg online for HIV or other STIs herpes 7 hours or less from treatment initiation. In an RCT (21), HIV-negative, sexually active men who inject drugs (STI/HSV-2 seronegative or HIV-negative) had sex with men who inject drugs (STI/HSV-2 seronegative or HIV-positive), receiving cART at 150 mg/d, were randomly allocated to receive once-weekly cART for 12 months with or without tenofovir alafenamide, at which time HIV seroconversion was considered as the primary end point. Both groups had a median of 36.6 ± 23.6 months from randomization to the 12-month cART regimen (p = 0.03). Of the 21 men who continued with cART, 10 had HIV-1 RNA (seroconversion/treatment interruption) greater than or equal to 1 × 10−8 (p = 0.0001) and 10 asymptomatic (no seroconversion/treatment interruption for 1–37 weeks). Of the 14 men who discontinued cART, none became seroconverted, with all 10 asymptomatic. This study showed that tenofovir alafenamide improves HIV seroconversion from cART in HIV-negative men who inject drugs. (Additional Figures.) Tenofovir alafenamide in combination with acyclovir is a possible treatment of herpes simplex infections and human immunodeficiency virus infection. A double-blind, placebo-controlled trial with acyclovir is currently under way in HIV-negative men who are seronegative for HSV-2 or a different serogroup who are concurrently receiving HIV cART. (Additional Figures.) Acyclovir (100 mg/kg) reduced viral buy valacyclovir uk load (VDRL) in 12 patients with herpes simplex or human immunodeficiency virus (HIV)-1 infection. In an unpublished double-blind, placebo-controlled study, acyclovir at dosages of 100 mg twice daily reduced viral load (VDRL) and replication (VDRL/RPR ratio) in 18 HIV-infected, unvaccinated gay men (age range, 34–72 years) with HSV-2. (Additional Figures.) Acyclovir was superior to darunavir in the treatment of seven patients with herpes simplex infections, including three of two infected heterosexual patients. At 12 weeks, the acyclovir group had a mean CD4 count of 773 cells/mm3, significantly fewer than the 586 cells/mm3 detected by standard of care. Four patients received acyclovir and one placebo. Two were on therapy for an additional 28 weeks. All patients had HSV-2 seropositivity. The acyclovir group had a significantly lower CD4 count (615/mm3 vs. 1,058/mm3, p = 0.03). (Additional Figures.) Acyclovir reduced HSV-2 latency in 18 patients with herpes simplex or human immunodeficiency virus (HIV)-1 infection, but the effect was modest. In a placebo-controlled trial, acyclovir 30 mg/day reduced latency to the 3 months or longer mark in a subset of four patients with HSV-2 seronegative for both HSV-1 and HSV-2. In an unpublished single-center, placebo-controlled, double-blind study in HIV-infected MSM with herpes simple.
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